Investigating early biomarkers of atopic diseases in children
Official title: Biomarkers of Atopy Beginning Early (BABE)
Funded at University of Rochester · NIH-11075802 · Data updated 2026-11-12
This study is looking at how atopic dermatitis and food allergies develop in young kids, especially those in farming communities, by working with Old Order Mennonites who seem to have fewer allergies, and it will involve collecting samples to find out what helps protect against these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 7, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $1,357,020 |
| NIH project number | 5U19AI175113-03 |
| Project ID | NIH-11075802 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation are children under 11 years old, particularly those with a family history of atopic diseases or living in farming environments.
✕Less likely to help
Patients with established severe atopic diseases or those outside the targeted age range may not benefit from this research.
What this research studies
This research focuses on understanding how atopic dermatitis and food allergies develop in young children, particularly those living in farming communities. By studying a group of Old Order Mennonites, who have lower rates of these conditions, the research aims to identify key factors such as skin barrier function, immune responses, and gut microbiome health that may protect against allergies. The study will involve collecting and analyzing biological samples over time to uncover the mechanisms behind these protective effects. Patients may be asked to participate in assessments and provide samples to help researchers gather valuable data.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating atopic diseases in children.
How similar studies have gone: Previous studies have shown that farming lifestyles can reduce the risk of asthma and allergies, suggesting that this research builds on established findings.
Where this research is happening
-
University of Rochester
Rochester, United States Active
Researchers
- Principal investigator: Jarvinen-Seppo, Kirsi — University of Rochester
- Study coordinator: Jarvinen-Seppo, Kirsi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.