Investigating drug resistance in HIV patients on Dolutegravir treatment
Official title: HIV-1 subtype, specific drug resistance in patients failing Dolutegravir-based 1st, 2nd or 3rd line regimens: the International epidemiological Databases to Evaluate AIDS (IeDEA)
Funded at Universitat Bern · NIH-10898745 · Data updated 2026-11-12
This study is looking at how some people with HIV-1 might not respond to the medication Dolutegravir, and it aims to find out why that happens so we can help improve treatment for both adults and teens living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Universitat Bern NIH-funded |
| Lab location | 1 site (Bern, SWITZERLAND) |
| Project start | September 1, 2021 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $844,255 |
| NIH project number | 5R01AI152772-04 |
| Project ID | NIH-10898745 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults and adolescents who are currently on Dolutegravir-based antiretroviral therapy and experiencing treatment failure.
✕Less likely to help
Patients who are not on Dolutegravir or those who have not experienced treatment failure may not benefit from this research.
What this research studies
This research focuses on understanding how HIV-1 can develop resistance to Dolutegravir, a key medication used in treating HIV. By analyzing data from various international cohorts, the study aims to identify patterns of drug resistance mutations in patients who are not responding to their treatment. It will also explore the risk factors that contribute to treatment failure in both adults and adolescents. The findings could help improve treatment strategies and patient outcomes in the fight against HIV.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for HIV patients experiencing drug resistance.
How similar studies have gone: Previous research has shown success in understanding drug resistance patterns in HIV, making this approach both relevant and necessary.
Where this research is happening
-
Universitat Bern
Bern, Switzerland Active
Researchers
- Principal investigator: Egger, Matthias — Universitat Bern
- Study coordinator: Egger, Matthias
Related research
Other NIH-funded projects on the same topics.
-
An integrated mobile health program to reduce SAVA and mental health problems among female sex workers in Kenya
A new mobile health program aims to help female sex workers in Kenya avoid substance abuse, violence, HIV, and depression by delivering group therapy, online resources, and a peer discussion space.
-
New thin, flexible tactile displays to make screens accessible for people who are blind
A new thin film technology will let touch-based screens mimic visual displays, helping people who are blind or visually impaired use phones and other devices.
-
FIOCRUZ HIV/AIDS Clinical Trials Unit: advancing HIV prevention and treatment in Brazil
A Brazilian clinical trials unit led by Dr. Beatriz Grinsztejn is testing and speeding up new HIV prevention and treatment strategies to help people living with HIV/AIDS and those at risk.
-
Breeding colony expansion to support HIV/AIDS research with rhesus macaques
A funding opportunity to expand a specialized Rhesus macaque breeding population to support HIV/AIDS research at Tulane’s primate facility.
-
HIV Resilience Observatory in a rhesus macaque colony expansion
A program to build a rhesus macaque breeding colony and use AI-powered monitoring to study why some HIV/AIDS outcomes differ among individuals with similar backgrounds.
-
Indoor-Outdoor Housing Expansion to Support HIV/AIDS-Related Research
A HIV-focused project at a primate research center will use new indoor/outdoor housing and AI-assisted monitoring to study why people with similar backgrounds can have very different HIV outcomes.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.