Investigating DNA repair gene mutations in prostate cancer
DNA repair gene mutations and prostate cancer
This study is looking at how certain gene changes related to DNA repair might increase the risk of prostate cancer, and it's for families who have been affected by this disease to help us learn more about the genetic factors involved.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beckman Research Institute/city of Hope NIH-funded |
| Lab location | 1 site (Duarte, United States) |
| Project ID | NIH-10771947 on NIH RePORTER |
What this research studies
This research focuses on understanding the genetic factors that contribute to prostate cancer, particularly through the lens of DNA repair gene mutations. By analyzing blood samples from families affected by prostate cancer, the study aims to identify specific genetic mutations that may increase the risk of developing this disease. The researchers utilize advanced sequencing techniques to uncover mutations in genes responsible for repairing DNA damage, which is crucial for maintaining genomic stability. This innovative approach could lead to a better understanding of how genetic predispositions influence prostate cancer risk.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of prostate cancer or those who have been diagnosed with the disease.
Not a fit: Patients without a family history of prostate cancer or those with sporadic cases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved genetic screening and targeted therapies for prostate cancer patients.
How similar studies have performed: Previous research has shown success in identifying genetic mutations related to cancer risk, suggesting that this approach may yield valuable insights.
Where this research is happening
Duarte, United States
- Beckman Research Institute/city of Hope — Duarte, United States (Active)
Researchers
- Principal investigator: Shen, Binghui — Beckman Research Institute/city of Hope
- Study coordinator: Shen, Binghui
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.