Investigating DNA methylation's role in placental development
DNA Methylation at N6-Adenine in Placental Trophoblast Development
This study is looking at how a special kind of DNA change affects the growth of cells that help connect a mother and her baby, which could help us understand issues like miscarriage and problems with the placenta, using experiments with mice, cows, and human cells.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10831027 on NIH RePORTER |
What this research studies
This research focuses on understanding how a specific type of DNA methylation, known as N6-adenine (N6-mA), influences the development of trophoblasts, which are crucial for fetal-maternal communication. By studying both mouse and bovine models, as well as human pluripotent stem cells, the researchers aim to uncover the molecular mechanisms that govern trophoblast lineage establishment and its implications for conditions like miscarriage and placental abnormalities. The approach involves advanced cell culture techniques and comparative studies across species to identify the roles of N6-mA in early embryonic development.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced recurrent miscarriages or have conditions related to placental abnormalities.
Not a fit: Patients with no history of miscarriage or placental issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and potential therapies for preventing miscarriages and improving placental health.
How similar studies have performed: While the specific focus on N6-mA in trophoblast development is novel, previous studies have shown success in understanding epigenetic marks in other contexts.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Jiang, Zongliang — University of Florida
- Study coordinator: Jiang, Zongliang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.