Investigating DNA changes related to PTSD in World Trade Center responders
Methylome profile of World Trade Center related PTSD
This study is looking at how our genes and the environment might work together to affect PTSD in people who responded to the 9/11 World Trade Center attack, using blood samples to find clues about these connections.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10903703 on NIH RePORTER |
What this research studies
This research focuses on understanding the biological factors contributing to PTSD experienced by responders of the 9/11 World Trade Center attack. By analyzing DNA methylation patterns in blood samples, the study aims to uncover how environmental factors interact with genetic predispositions to influence PTSD symptoms. The research will utilize advanced genome-wide methylation profiling techniques to gather comprehensive data, which will be combined with existing datasets to enhance the robustness of the findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who were responders during the 9/11 World Trade Center attack and are experiencing PTSD symptoms.
Not a fit: Patients who were not involved in the 9/11 incident or do not exhibit PTSD symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the identification of biological markers for PTSD, improving diagnosis and treatment options for affected individuals.
How similar studies have performed: Previous research has shown promise in identifying epigenetic markers related to PTSD, but this study aims to enhance the power and generalizability of findings through a larger and more diverse dataset.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Kuan, Pei-Fen — State University New York Stony Brook
- Study coordinator: Kuan, Pei-Fen
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.