Investigating DNA changes related to breast cancer risk
DNA Methylation Markers, Genes and Breast Cancer Risk
['FUNDING_R01'] · VANDERBILT UNIVERSITY MEDICAL CENTER · NIH-11056085
This study is looking at how changes in DNA might affect the risk of breast cancer in women from different backgrounds, with the hope of finding patterns that could help improve prevention strategies.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | VANDERBILT UNIVERSITY MEDICAL CENTER (nih funded) |
| Locations | 1 site (NASHVILLE, UNITED STATES) |
| Trial ID | NIH-11056085 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how DNA methylation, a key epigenetic modification, influences breast cancer risk. By analyzing genetic data from diverse populations, including women of African, Asian, and European ancestry, the study aims to identify specific DNA methylation patterns associated with breast cancer. The researchers will use advanced statistical models to predict these patterns and assess their relationship with breast cancer occurrence. This approach could help uncover the underlying mechanisms linking genetics and breast cancer, potentially leading to better prevention strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include cancer-free women of African, Asian, or European ancestry who are interested in understanding their breast cancer risk.
Not a fit: Patients with a current diagnosis of breast cancer or those not belonging to the specified ancestry groups may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting breast cancer risk and developing targeted prevention strategies.
How similar studies have performed: Previous research has shown promise in using genetic and epigenetic data to understand cancer risk, indicating that this approach could yield valuable insights.
Where this research is happening
NASHVILLE, UNITED STATES
- VANDERBILT UNIVERSITY MEDICAL CENTER — NASHVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LONG, JIRONG — VANDERBILT UNIVERSITY MEDICAL CENTER
- Study coordinator: LONG, JIRONG
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.