Investigating DNA changes in lung tumors
DNA hypermethylation in lung tumors
This study is looking at how changes in DNA can affect lung tumors, and it's for anyone interested in understanding more about how cancer develops and what might help in treating it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project ID | NIH-10683173 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA hypermethylation affects lung tumors, a common feature in cancer cells. The team will explore the mechanisms behind these methylation changes, particularly at specific DNA regions known as CpG islands. By studying proteins that interact with these regions, the research aims to uncover how certain genes are protected from becoming hypermethylated, which could lead to better insights into cancer development and potential treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with lung tumors or those at high risk for developing lung cancer.
Not a fit: Patients with non-cancerous conditions or those without lung tumors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for lung cancer patients.
How similar studies have performed: Previous research has shown that understanding DNA methylation patterns can lead to significant advancements in cancer treatment, indicating that this approach has potential for success.
Where this research is happening
Grand Rapids, United States
- Van Andel Research Institute — Grand Rapids, United States (Active)
Researchers
- Principal investigator: Pfeifer, Gerd P — Van Andel Research Institute
- Study coordinator: Pfeifer, Gerd P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.