Investigating DNA changes in lung cells of patients with idiopathic pulmonary fibrosis.
Official title: Heterogeneity and Regulation of the DNA Methylome in IPF Mesenchymal Cells
Funded at University of Michigan at Ann Arbor · NIH-10984968 · Data updated 2026-11-12
This study is looking at how changes in DNA might affect lung cells in people with idiopathic pulmonary fibrosis (IPF) to help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project start | February 1, 2023 |
| Project end | November 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $550,004 |
| NIH project number | 5R01HL162963-03 |
| Project ID | NIH-10984968 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis.
✕Less likely to help
Patients with other forms of lung disease or those without a diagnosis of idiopathic pulmonary fibrosis may not benefit from this research.
What this research studies
This research focuses on understanding how DNA methylation affects the behavior of lung cells in patients with idiopathic pulmonary fibrosis (IPF). By analyzing the differences in DNA methylation patterns between healthy and IPF lung cells, the study aims to uncover the mechanisms that lead to the disease's progression. The researchers will use advanced techniques to assess the genetic profiles of these cells and identify factors that influence DNA methylation. This could provide insights into potential therapeutic targets for IPF.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of idiopathic pulmonary fibrosis.
How similar studies have gone: Previous research has shown promising results in understanding the role of DNA methylation in other diseases, suggesting that this approach could yield valuable insights for IPF as well.
Where this research is happening
-
University of Michigan at Ann Arbor
Ann Arbor, United States Active
Researchers
- Principal investigator: Huang, Steven K — University of Michigan at Ann Arbor
- Study coordinator: Huang, Steven K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.