Investigating DNA changes in lung cells of patients with idiopathic pulmonary fibrosis.
Heterogeneity and Regulation of the DNA Methylome in IPF Mesenchymal Cells
This study is looking at how changes in DNA might affect lung cells in people with idiopathic pulmonary fibrosis (IPF) to help find new ways to treat the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10984968 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA methylation affects the behavior of lung cells in patients with idiopathic pulmonary fibrosis (IPF). By analyzing the differences in DNA methylation patterns between healthy and IPF lung cells, the study aims to uncover the mechanisms that lead to the disease's progression. The researchers will use advanced techniques to assess the genetic profiles of these cells and identify factors that influence DNA methylation. This could provide insights into potential therapeutic targets for IPF.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with idiopathic pulmonary fibrosis.
Not a fit: Patients with other forms of lung disease or those without a diagnosis of idiopathic pulmonary fibrosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that slow down or reverse the progression of idiopathic pulmonary fibrosis.
How similar studies have performed: Previous research has shown promising results in understanding the role of DNA methylation in other diseases, suggesting that this approach could yield valuable insights for IPF as well.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Huang, Steven K — University of Michigan at Ann Arbor
- Study coordinator: Huang, Steven K
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.