Investigating DNA changes in colon cancer related to racial differences
Full Research Project 2: Changes in DNA methylation phenotype in CRC associated with racial disparities
['FUNDING_OTHER'] · TEMPLE UNIV OF THE COMMONWEALTH · NIH-10931744
This study is looking at how certain changes in DNA might help us find out who is more likely to get colorectal cancer, especially focusing on African Americans compared to Caucasian Americans, so we can improve early detection and prevention for everyone.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | TEMPLE UNIV OF THE COMMONWEALTH (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10931744 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how DNA methylation patterns differ in individuals with colorectal cancer (CRC), particularly among African Americans compared to Caucasian Americans. The study aims to identify early biomarkers that can help distinguish between individuals at high risk and those at low risk for CRC. By analyzing blood samples and colon tissue, the researchers hope to uncover specific genetic changes that could lead to better screening and prevention strategies. The ultimate goal is to reduce the higher rates of CRC incidence and mortality observed in African American populations.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American individuals at high risk for colorectal cancer due to genetic or environmental factors.
Not a fit: Patients who are not of African descent or those who do not have a family history of colorectal cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for colorectal cancer, particularly benefiting African American patients.
How similar studies have performed: Previous research has shown promising results in identifying epigenetic markers related to colorectal cancer, suggesting that this approach may be effective.
Where this research is happening
PHILADELPHIA, UNITED STATES
- TEMPLE UNIV OF THE COMMONWEALTH — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SAPIENZA, CARMEN — TEMPLE UNIV OF THE COMMONWEALTH
- Study coordinator: SAPIENZA, CARMEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.