Investigating DNA changes in brain cells related to Alzheimer's disease
DNA Methylation Signatures of Alzheimer's Disease in Aged Astrocyte
This study is looking at how changes in DNA affect brain cells called astrocytes in people with Alzheimer's disease, using skin cells turned into astrocytes to help us understand what happens as we age and how it might lead to the disease, with the hope of finding new ways to help.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas San Antonio NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project ID | NIH-11128055 on NIH RePORTER |
What this research studies
This research focuses on understanding how DNA methylation, a type of epigenetic modification, affects astrocytes, which are non-neuronal cells in the brain, in the context of Alzheimer's disease (AD). The study aims to develop a model using adult human fibroblasts converted into astrocytes to mimic age-related changes in DNA and gene expression. By examining these changes, the research seeks to uncover the role of astrocytes in AD progression and how they contribute to the disease's pathology. This approach could provide insights into the mechanisms of AD and potential therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who may be at risk for or are experiencing symptoms of Alzheimer's disease.
Not a fit: Patients with early-onset Alzheimer's disease or those under 21 years old may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing or treating Alzheimer's disease by targeting the role of astrocytes and their epigenetic changes.
How similar studies have performed: While the specific approach of using fibroblast-derived astrocytes is novel, there is existing research indicating that studying epigenetic changes in brain cells can provide valuable insights into Alzheimer's disease.
Where this research is happening
San Antonio, United States
- University of Texas San Antonio — San Antonio, United States (Active)
Researchers
- Principal investigator: Carless, Melanie — University of Texas San Antonio
- Study coordinator: Carless, Melanie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.