Investigating diuretic treatment for infants with bronchopulmonary dysplasia
Official title: Pragmatic Research on Diuretic Management in Early BPD (PRIMED) Pilot
Funded at Cincinnati Childrens Hosp Med Ctr · NIH-11009525 · Data updated 2026-11-12
This study is looking at whether a type of medicine called loop diuretics, like furosemide, can help improve breathing in preterm babies with a lung condition called bronchopulmonary dysplasia, while also keeping an eye on any side effects.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cincinnati Childrens Hosp Med Ctr NIH-funded |
| Lab location | 1 site (Cincinnati, United States) |
| Project start | January 1, 2023 |
| Project end | December 31, 2025 |
| Funding year | 2025 |
| Award (this year) | $245,507 |
| NIH project number | 5R34HL158586-03 |
| Project ID | NIH-11009525 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are preterm infants born at less than 30 weeks gestation who are diagnosed with early bronchopulmonary dysplasia and are over three weeks old.
✕Less likely to help
Patients who are not preterm or do not have a diagnosis of bronchopulmonary dysplasia may not benefit from this research.
What this research studies
This research focuses on understanding how diuretics, specifically loop diuretics like furosemide, can help improve lung function in preterm infants diagnosed with bronchopulmonary dysplasia (BPD). The study will assess whether these medications can enhance pulmonary mechanics and oxygenation in infants over three weeks old, while also monitoring for potential side effects. By including a run-in period, the research aims to identify which infants may benefit from this treatment in the current medical context, characterized by advanced therapies like surfactant and corticosteroids. The goal is to provide clearer evidence on the safety and effectiveness of diuretics for these vulnerable patients.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment protocols for infants with bronchopulmonary dysplasia, enhancing their respiratory health and overall outcomes.
How similar studies have gone: While there is some evidence suggesting potential benefits of diuretics in similar contexts, this research aims to fill gaps in knowledge due to the lack of robust studies conducted in the current treatment era.
Where this research is happening
-
Cincinnati Childrens Hosp Med Ctr
Cincinnati, United States Active
Researchers
- Principal investigator: Kaplan, Heather Cecille — Cincinnati Childrens Hosp Med Ctr
- Study coordinator: Kaplan, Heather Cecille
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.