Investigating different types of pancreatic beta cells in diabetes
Official title: Understanding putative beta-cell subtypes
Funded at Van Andel Research Institute · NIH-10998630 · Data updated 2026-11-12
This study is looking at different types of cells in the pancreas that help control blood sugar in people with Type 2 diabetes, to find out how they work and communicate, which could lead to new ways to treat or manage the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Van Andel Research Institute NIH-funded |
| Lab location | 1 site (Grand Rapids, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $698,646 |
| NIH project number | 1R01DK139630-01A1 |
| Project ID | NIH-10998630 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with Type 2 diabetes who are interested in understanding the cellular mechanisms of their condition.
✕Less likely to help
Patients with Type 1 diabetes or those without any form of diabetes may not benefit from this research.
What this research studies
This research focuses on understanding the various subtypes of pancreatic beta cells that play a crucial role in regulating blood sugar levels in individuals with Type 2 diabetes. The team will analyze how these beta cell subtypes respond to glucose and communicate with each other, using advanced techniques to isolate and study these cells. By examining the genetic and epigenetic factors that differentiate these cell types, the research aims to uncover their roles in diabetes progression and potential therapeutic targets. Patients may benefit from insights that could lead to new treatments or interventions for managing diabetes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Type 2 diabetes by targeting specific beta cell functions.
How similar studies have gone: Previous research has shown promise in understanding beta cell function and differentiation, indicating that this approach could yield valuable insights.
Where this research is happening
-
Van Andel Research Institute
Grand Rapids, United States Active
Researchers
- Principal investigator: Pospisilik, John Andrew — Van Andel Research Institute
- Study coordinator: Pospisilik, John Andrew
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.