Investigating different types and causes of early onset Parkinson's disease
Official title: Early Onset Parkinson’s disease subtypes and pathogenic mechanisms
Funded at New York University School of Medicine · NIH-10910144 · Data updated 2026-11-12
This study is looking at different types of early onset Parkinson's disease in people under 50 to find out how genetics, inflammation, and a specific protein affect the disease, so we can create more personalized treatment plans for each type.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $671,231 |
| NIH project number | 5R01NS133742-02 |
| Project ID | NIH-10910144 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with early onset Parkinson's disease, particularly those who developed symptoms before the age of 50.
✕Less likely to help
Patients with late onset Parkinson's disease or those without a diagnosis of Parkinson's disease may not benefit from this research.
What this research studies
This research focuses on understanding the various subtypes of early onset Parkinson's disease (EOPD), which occurs in individuals under 50 years old. By examining the roles of genetics, inflammation, and the accumulation of a protein called alpha-synuclein, the study aims to classify patients into distinct groups based on their specific pathogenic mechanisms. This approach will involve analyzing clinical and genetic profiles, as well as biosamples from patients, to better understand how these factors contribute to the disease. The ultimate goal is to enhance precision medicine by identifying tailored treatment strategies for different EOPD subtypes.
Why it matters
Potential benefit: If successful, this research could lead to more personalized and effective treatment options for patients with early onset Parkinson's disease.
How similar studies have gone: Previous research has shown promise in stratifying Parkinson's disease patients based on genetic and biochemical markers, suggesting that this approach could yield valuable insights.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Riboldi, Giulietta Maria — New York University School of Medicine
- Study coordinator: Riboldi, Giulietta Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.