Investigating differences in immune cells between Alzheimer's and HIV-related cognitive issues
Harnessing Single Cell Epigenome-wide profiling of Myeloid cells to Compare and Contrast Alzheimer's from HIV-Associated Cognitive Dysfunction
This study is looking at how to tell the difference between Alzheimer's disease and cognitive issues related to HIV in people over 60 by examining blood samples for unique markers, which could help doctors diagnose these conditions more accurately and improve care for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10799613 on NIH RePORTER |
What this research studies
This research focuses on understanding how cognitive impairment in individuals over 60 years old can be differentiated between Alzheimer's disease and HIV-associated cognitive dysfunction. By analyzing myeloid cells using advanced single-cell epigenome profiling, the study aims to identify unique immune biomarkers that can help in diagnosing these conditions more accurately. The approach involves examining blood samples to uncover specific epigenetic signatures that may indicate the presence of either condition. This could lead to improved diagnostic methods and better patient management.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals over 60 years old who are living with HIV and experiencing cognitive impairment.
Not a fit: Patients who are not over 60 years old or do not have HIV-related cognitive issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and tailored treatments for older adults experiencing cognitive decline related to either Alzheimer's or HIV.
How similar studies have performed: Previous research has shown promise in using epigenetic profiling to differentiate between various cognitive disorders, suggesting that this approach may yield valuable insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Ndhlovu, Lishomwa C — Weill Medical Coll of Cornell Univ
- Study coordinator: Ndhlovu, Lishomwa C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.