Investigating deep brain stimulation to treat severe chronic pain
A staged, comprehensive investigation for developing insular deep brain stimulation to treat refractory chronic pain
['FUNDING_OTHER'] · UNIVERSITY OF VIRGINIA · NIH-10918114
This study is looking at how deep brain stimulation can help people with chronic pain that doesn't get better with regular medications, starting with some brain mapping to find the best spots to stimulate, and if it works well, those who benefit will continue in a trial to see how safe and effective it is over time.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF VIRGINIA (nih funded) |
| Locations | 1 site (CHARLOTTESVILLE, UNITED STATES) |
| Trial ID | NIH-10918114 on ClinicalTrials.gov |
What this research studies
This research explores the use of deep brain stimulation (DBS) as a treatment for patients suffering from refractory chronic pain, which often does not respond to standard pain medications. Initially, 12 participants will undergo brain mapping and acute stimulation to identify effective stimulation sites in the insular cortex. Those who experience positive results will then participate in a controlled trial to assess the long-term safety and efficacy of chronic DBS. The study also aims to develop biomarkers that can help understand pain mechanisms better.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from refractory chronic neuropathic pain who have not responded to conventional pain management strategies.
Not a fit: Patients with chronic pain that responds well to standard analgesics or those with conditions not related to neuropathic pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a new, effective treatment option for patients with chronic pain who have not found relief through traditional therapies.
How similar studies have performed: Previous research has shown promise in using deep brain stimulation for other conditions, suggesting potential for success in this novel application for chronic pain.
Where this research is happening
CHARLOTTESVILLE, UNITED STATES
- UNIVERSITY OF VIRGINIA — CHARLOTTESVILLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ELIAS, WILLIAM JEFFREY — UNIVERSITY OF VIRGINIA
- Study coordinator: ELIAS, WILLIAM JEFFREY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.