Investigating Cystic Fibrosis using Stem Cells
Using Induced Pluripotent Stem Cells to Characterize Cystic Fibrosis
This study is looking at how different genetic types of Cystic Fibrosis affect lung function by creating lung cells from patients' stem cells, with the goal of finding better treatments for people living with CF.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11086620 on NIH RePORTER |
What this research studies
This research focuses on understanding Cystic Fibrosis (CF) by using induced pluripotent stem cells (iPSCs) to create airway epithelial cells. These cells are derived from patients with different CF phenotypes, allowing researchers to study how genetic variations affect lung function. The project aims to model the disease in a lab setting to explore the mechanisms behind CF and test potential treatments. By analyzing how these cells behave, the research seeks to uncover insights that could lead to improved therapies for CF patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with Cystic Fibrosis, particularly those with specific genetic mutations like homozygous F508del CFTR.
Not a fit: Patients without Cystic Fibrosis or those with unrelated lung conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve lung function and quality of life for Cystic Fibrosis patients.
How similar studies have performed: Previous research has shown promise in using stem cell models to study genetic diseases, indicating that this approach could yield valuable insights for Cystic Fibrosis.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Wang, Ruobing — Boston Children's Hospital
- Study coordinator: Wang, Ruobing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.