Investigating copper toxicity and its effects on the brain in a mouse model of Wilson Disease
The Atp7b-/- mouse model of neurological copper toxicity and Wilson Disease
This study is looking at Wilson Disease, a condition that causes too much copper to build up in the body, and it's testing new treatments, like zinc salts, to see if they can help reduce harmful effects on the brain and liver while being safer than current medications.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alaska Anchorage NIH-funded |
| Lab location | 1 site (Anchorage, United States) |
| Project ID | NIH-10574028 on NIH RePORTER |
What this research studies
This research focuses on Wilson Disease, a genetic disorder that leads to harmful copper buildup in the body, particularly affecting the brain and liver. Using a specific mouse model, researchers aim to understand how copper toxicity contributes to neurological symptoms such as movement disorders and psychiatric issues. The study explores alternative treatments, like zinc salts, which may be less harmful to neurological health compared to traditional copper-lowering drugs. By examining the mechanisms of copper toxicity, the research seeks to improve treatment strategies for patients with Wilson Disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Wilson Disease, particularly those experiencing neurological symptoms.
Not a fit: Patients without Wilson Disease or those whose symptoms are not related to copper metabolism may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for patients with Wilson Disease, potentially reducing neurological symptoms and improving quality of life.
How similar studies have performed: Previous research using rodent models has successfully identified mechanisms of copper toxicity, suggesting that this approach may yield valuable insights for Wilson Disease treatment.
Where this research is happening
Anchorage, United States
- University of Alaska Anchorage — Anchorage, United States (Active)
Researchers
- Principal investigator: Burkhead, Jason L — University of Alaska Anchorage
- Study coordinator: Burkhead, Jason L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.