Investigating copper proteins and their role in managing reactive oxygen species in cells
Cuproproteins for Redox Biology
['FUNDING_OTHER'] · JOHNS HOPKINS UNIVERSITY · NIH-10791778
This study is looking at special proteins that contain copper and help our cells deal with harmful substances that can cause damage, and it's for anyone interested in how these proteins work to keep our cells healthy and protect us from infections.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10791778 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how copper-containing proteins, specifically superoxide dismutases (SODs), help cells manage reactive oxygen species (ROS) like superoxide and hydrogen peroxide. By studying a newly discovered class of copper-only SODs found in fungi and animals, the research aims to uncover their unique properties and functions in balancing the harmful and beneficial effects of ROS. The approach involves detailed biochemical analysis and genetic studies to explore how these proteins contribute to cellular health and pathogen defense.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with conditions that involve oxidative stress or related metabolic disorders.
Not a fit: Patients with non-oxidative stress-related conditions may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing cellular protection against oxidative stress, potentially benefiting patients with conditions related to oxidative damage.
How similar studies have performed: Previous research has shown promising results in understanding the role of antioxidant enzymes in cellular protection, indicating that this area of study has potential for significant advancements.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CULOTTA, VALERIA C — JOHNS HOPKINS UNIVERSITY
- Study coordinator: CULOTTA, VALERIA C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.