Investigating conditions that mimic Alzheimer's disease using advanced imaging techniques
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanning
This study is looking at other diseases that can look like Alzheimer's to help doctors make better diagnoses and treatment plans, using advanced scanning technology and brain images from autopsies to find important differences.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11004154 on NIH RePORTER |
What this research studies
This research focuses on identifying and understanding diseases that can mimic Alzheimer's disease, which complicates accurate diagnosis and treatment. By utilizing advanced 3D scanning and machine learning techniques on dissection photographs from brain autopsies, the study aims to uncover distinct anatomical features of these mimicking conditions. Collaborating with Alzheimer’s Research Centers, the project seeks to correlate these features with clinical data to improve diagnostic accuracy and patient care. Ultimately, the findings could lead to better identification of Alzheimer's and related disorders, enhancing treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with late-life dementia who may have overlapping conditions with Alzheimer's disease.
Not a fit: Patients with confirmed Alzheimer's disease without any mimicking conditions may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses of Alzheimer's disease and its mimics, improving treatment strategies for patients.
How similar studies have performed: Previous research has shown promise in using advanced imaging techniques for neurological conditions, suggesting potential success for this novel approach.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Iglesias Gonzalez, Juan Eugenio — Massachusetts General Hospital
- Study coordinator: Iglesias Gonzalez, Juan Eugenio
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.