Investigating components of HIV-1 for vaccine development
Official title: Exploring the membrane-related components of HIV-1 Env for immunogen design
Funded at Boston Children's Hospital · NIH-10892869 · Data updated 2026-11-12
This study is looking at parts of the HIV virus that help it infect cells, to find out how we can create better vaccines that help the body fight off HIV, and it's being tested in animals to see how different versions of these parts can help produce strong antibodies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | July 24, 2023 |
| Project end | June 30, 2027 |
| Funding year | 2024 |
| Award (this year) | $784,041 |
| NIH project number | 5R01AI174938-02 |
| Project ID | NIH-10892869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would include individuals at high risk for HIV infection or those living with HIV.
✕Less likely to help
Patients who are not at risk for HIV or those who are already receiving effective treatment may not benefit from this research.
What this research studies
This research focuses on understanding the membrane-related components of the HIV-1 envelope glycoprotein, which are crucial for designing effective vaccines. The team will explore how different regions of the protein influence its stability and the immune response it generates. By using animal models, they aim to determine how various configurations of these components can lead to the production of broadly neutralizing antibodies. This approach could pave the way for innovative strategies in HIV vaccine development.
Why it matters
Potential benefit: If successful, this research could lead to the development of a more effective HIV vaccine that elicits strong immune responses.
How similar studies have gone: Previous research has shown promise in using similar approaches to induce immune responses in animal models, suggesting potential for success in this area.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: Chen, Bing — Boston Children's Hospital
- Study coordinator: Chen, Bing
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.