Investigating complications from radiation therapy in HPV-related throat cancer
Project 1: OPC-ORN
This study is looking at how radiation treatment for HPV-related throat cancer can sometimes lead to a painful bone problem called osteoradionecrosis, and it aims to find ways to spot this issue early so that we can help improve the lives of cancer survivors.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10933255 on NIH RePORTER |
What this research studies
This research focuses on the complications that arise from external beam radiotherapy (EBRT) in patients with human papillomavirus (HPV)-associated oropharyngeal cancer (OPC). It aims to identify and monitor osteoradionecrosis (ORN), a painful and severe bone-related complication that can occur after treatment. The study will utilize advanced imaging techniques to detect early signs of ORN, allowing for better management and prevention strategies. By understanding the incidence and symptom progression of ORN, the research seeks to improve the quality of life for cancer survivors.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have been treated for HPV-associated oropharyngeal cancer and are experiencing or at risk for complications from radiation therapy.
Not a fit: Patients who have not undergone radiation therapy for oropharyngeal cancer or those with other unrelated health conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved detection and management of painful complications in cancer survivors, enhancing their quality of life.
How similar studies have performed: Previous research has shown promise in identifying biomarkers for treatment-related complications in cancer patients, suggesting that this approach may yield valuable insights.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Lai, Stephen Y — University of Tx Md Anderson Can Ctr
- Study coordinator: Lai, Stephen Y
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.