Investigating communication issues between mitochondria and the endoplasmic reticulum in mitochondrial diseases
Aberrant ER-Mitochondria Communication in Human Mitochondrial Disease
This study is looking at how problems with communication between two important parts of your cells, called mitochondria and the endoplasmic reticulum, can lead to mitochondrial diseases, and it hopes to find new ways to help people with these conditions feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10874454 on NIH RePORTER |
What this research studies
This research focuses on understanding how defects in the communication between mitochondria and the endoplasmic reticulum contribute to mitochondrial diseases, which are complex disorders affecting energy production in cells. The study examines the biochemical and physical interactions at specialized membrane sites, known as mitochondria-associated ER membranes (MAM), to uncover how these disruptions impact cellular functions. By analyzing patient-derived cells, the research aims to identify the underlying mechanisms of these diseases and explore potential therapeutic targets to improve patient outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with mitochondrial diseases, particularly those with neurodegenerative symptoms.
Not a fit: Patients with mitochondrial diseases caused solely by environmental factors or those without genetic mutations affecting mitochondrial function may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve energy metabolism and overall health for patients with mitochondrial diseases.
How similar studies have performed: Previous research has shown promising results in understanding mitochondrial dysfunction and its implications, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Schon, Eric a. — Columbia University Health Sciences
- Study coordinator: Schon, Eric a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.