Investigating collagen changes in heart disease
Molecular Imaging of Collagen Turnover in Cardiomyopathy
This study is looking at how changes in collagen in the heart relate to cardiomyopathy, a common cause of heart failure, and aims to create easy-to-use imaging tools that can help doctors see these changes, so they can find the right treatments for patients and see how well those treatments are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10888197 on NIH RePORTER |
What this research studies
This research focuses on understanding how collagen turnover affects heart disease, specifically cardiomyopathy, which is a leading cause of heart failure. By using advanced imaging techniques, the study aims to develop non-invasive tools that can measure collagen changes in the heart, providing insights into the progression of the disease. This approach will help identify patients who may benefit from new therapies and track how well these treatments are working over time. The goal is to improve patient outcomes by better understanding the fibrotic processes involved in heart disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cardiomyopathy or related heart conditions.
Not a fit: Patients with heart conditions unrelated to collagen turnover or those without a diagnosis of cardiomyopathy may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and treatment strategies for patients with heart disease.
How similar studies have performed: Other research has shown promise in using molecular imaging techniques to assess fibrosis, indicating that this approach may yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sadeghi, Mehran M — Yale University
- Study coordinator: Sadeghi, Mehran M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.