Investigating cognitive resilience in centenarians and their families
Phenotyping and Biospecimen Core
['FUNDING_OTHER'] · BOSTON UNIVERSITY MEDICAL CAMPUS · NIH-10907585
This study is looking for amazing older adults who are 100 years or older and still have sharp minds, along with their children and partners, to help us learn more about what keeps their brains healthy as they age, by doing yearly brain tests and blood tests to check for signs of Alzheimer's.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BOSTON UNIVERSITY MEDICAL CAMPUS (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10907585 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying centenarians who exhibit exceptional cognitive abilities, known as cognitive superagers, along with their offspring and spouses. Participants will undergo annual neuropsychological testing and provide blood samples to analyze biomarkers related to Alzheimer's disease. The study aims to understand the factors contributing to cognitive resilience and resistance to cognitive impairment in older adults. Additionally, neuroimaging and post-mortem studies will be conducted among willing participants to gather further insights.
Who could benefit from this research
Good fit: Ideal candidates for this research include centenarians aged 100-110 years, their offspring, and spouses of the offspring.
Not a fit: Patients who are younger than 100 years or do not have a familial connection to the centenarians being studied may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to breakthroughs in understanding and potentially preventing Alzheimer's disease and cognitive decline in older adults.
How similar studies have performed: Previous research has shown promise in studying cognitive resilience in older populations, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- BOSTON UNIVERSITY MEDICAL CAMPUS — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDERSEN, STACY — BOSTON UNIVERSITY MEDICAL CAMPUS
- Study coordinator: ANDERSEN, STACY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome