Investigating cognitive deficits in Parkinson's disease related to cholinergic dysfunction
Project III: Cingulo-Opercular Task Control Network Cholinergic Dysfunction in PD
This study is looking at how Parkinson's disease affects thinking and memory in people who don't get better with regular treatments, so we can find better, personalized ways to help them feel more like themselves again.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10931698 on NIH RePORTER |
What this research studies
This research focuses on understanding the cognitive deficits experienced by individuals with Parkinson's disease (PD), particularly those that do not respond to standard dopamine replacement therapies. It aims to explore the complex interactions of various brain systems involved in cognitive function, especially in the early to moderate stages of PD. By identifying specific subgroups of PD patients and their unique cognitive impairments, the study seeks to develop personalized therapies and improve clinical outcomes. The research utilizes advanced imaging techniques to assess cholinergic deficits in key brain regions associated with cognitive control.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Parkinson's disease who are experiencing cognitive deficits, particularly those who have not responded well to dopamine replacement therapies.
Not a fit: Patients with Parkinson's disease who do not exhibit cognitive deficits or those in advanced stages of the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatments for cognitive impairments in Parkinson's disease.
How similar studies have performed: Previous research has shown promise in understanding cognitive impairments in Parkinson's disease through similar approaches, indicating potential for success in this study.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Albin, Roger L — University of Michigan at Ann Arbor
- Study coordinator: Albin, Roger L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.