Investigating cognitive decline and dementia risks in former soccer and football players.

Risk for Later-Life Cognitive Impairment, Neurobehavioral Dysregulation, and Dementia in Former Soccer and American Football Players: The Head Impact and Trauma Surveillance Study (HITSS)

NIH-funded research Boston University Medical Campus · NIH-11045055

This study is looking at how repeated head injuries from sports like soccer and football might affect brain health and thinking skills as athletes get older, and it’s for both male and female athletes who want to help us learn more about these long-term effects.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionBoston University Medical Campus NIH-funded
Lab location1 site (Boston, United States)
Project IDNIH-11045055 on NIH RePORTER

What this research studies

This research examines how repetitive head impacts from contact sports like soccer and American football may lead to cognitive decline and neurobehavioral issues later in life. By analyzing data from the Brain Health Registry, the study aims to identify risk factors and the prevalence of cognitive impairment and dementia in both male and female athletes. The approach includes a longitudinal analysis to address previous limitations in research, such as small sample sizes and biases. Participants will provide valuable information that could help understand the long-term effects of head injuries in sports.

Who could benefit from this research

Good fit: Ideal candidates for this research are former soccer and American football players, both male and female, who have experienced head impacts during their sports careers.

Not a fit: Patients who have not participated in contact sports or do not have a history of head impacts may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could lead to improved understanding and prevention strategies for cognitive decline and dementia in former athletes.

How similar studies have performed: Previous research has shown promising results in understanding the cognitive effects of head impacts in male athletes, but this study aims to expand knowledge to include female athletes and address existing gaps.

Where this research is happening

Boston, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndrome
Last reviewed 2026-06-10 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.