Investigating cognitive decline and dementia risk in older adults through advanced assessments.
Precision Monitoring and Assessment in the Framingham Study: Cognitive, MRI, Genetic and Biomarker Precursors of AD & Dementia
This study is looking at how Alzheimer's and dementia develop over time by tracking people from the Framingham Heart Study, using brain scans and tests to spot early signs of memory and thinking problems, and it’s designed for anyone interested in understanding the genetic factors that might increase the risk of these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10903930 on NIH RePORTER |
What this research studies
This research focuses on understanding the precursors of Alzheimer's disease and dementia by monitoring participants from the Framingham Heart Study over several decades. It utilizes neuropsychological assessments, brain MRI scans, and genetic and biomarker data to identify early signs of cognitive decline. The study aims to capture detailed changes in cognitive function through innovative methods, including digital responses, to enhance detection of preclinical conditions. By analyzing data from multiple generations, the research seeks to uncover genetic factors associated with dementia risk.
Who could benefit from this research
Good fit: Ideal candidates for participation are older adults, particularly those from the Framingham Heart Study cohorts, who are at risk for cognitive decline.
Not a fit: Patients who are not part of the Framingham Heart Study or those who are not at risk for cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and better understanding of Alzheimer's disease and dementia, potentially improving patient outcomes.
How similar studies have performed: Previous research has shown success in identifying genetic associations with Alzheimer's disease using similar longitudinal approaches.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Farrer, Lindsay a. — Boston University Medical Campus
- Study coordinator: Farrer, Lindsay a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.