Investigating cognitive decline and dementia in older patients with kidney disease
Official title: Cognitive Decline and Incident Dementia in Older Patients with Secondary Hyperparathyroidism
Funded at Johns Hopkins University · NIH-11015789 · Data updated 2026-11-12
This study is looking at how high levels of a hormone related to kidney disease might affect thinking and memory in older adults with severe kidney problems, hoping to find ways to help improve their brain health and overall quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | February 15, 2023 |
| Project end | January 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $724,365 |
| NIH project number | 5R01AG076834-03 |
| Project ID | NIH-11015789 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults aged 55 and above who are living with end-stage renal disease.
✕Less likely to help
Patients who are younger than 55 or do not have end-stage renal disease may not benefit from this research.
What this research studies
This research focuses on older adults with end-stage renal disease (ESRD) to understand how secondary hyperparathyroidism (SHPT) may contribute to cognitive decline and the development of dementia. The study will analyze the relationship between high levels of parathyroid hormone and cognitive impairment, using biomarkers to assess their impact on brain function. By identifying modifiable risk factors, the research aims to improve the quality of life for patients suffering from cognitive issues related to kidney disease.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and dementia in older patients with kidney disease.
How similar studies have gone: Previous research has indicated a correlation between parathyroid hormone levels and cognitive impairment, suggesting that this approach may yield valuable insights.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Mathur, Aarti — Johns Hopkins University
- Study coordinator: Mathur, Aarti
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.