Investigating cognitive decline and aging effects from chemotherapy using baboons
Official title: Baboon model of chemotherapy-related cognitive impairment and accelerated aging
Funded at University of Tx Md Anderson Can Ctr · NIH-10901848 · Data updated 2026-11-12
This study is looking at how chemotherapy might affect thinking and brain aging in cancer patients, using baboons to help us understand these changes better, with the hope of finding ways to help people who experience these side effects.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project start | August 15, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| Award (this year) | $188,282 |
| NIH project number | 5K01AG078411-03 |
| Project ID | NIH-10901848 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are cancer patients who are undergoing chemotherapy and may experience cognitive impairments or accelerated aging.
✕Less likely to help
Patients who are not undergoing chemotherapy or those with pre-existing cognitive impairments unrelated to cancer treatment may not benefit from this research.
What this research studies
This research focuses on understanding the cognitive impairments and accelerated aging that can occur as a result of chemotherapy treatment for cancer. By using a baboon model, which is more similar to humans than traditional rodent models, the study aims to explore how chemotherapy affects brain function and aging. Researchers will collect various data, including brain imaging and cognitive assessments, before and after treatment with chemotherapy and a potential therapeutic intervention. The goal is to gain insights that could lead to effective treatments for patients experiencing these side effects.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that mitigate cognitive decline and aging effects in cancer survivors.
How similar studies have gone: While research on chemotherapy-related cognitive impairments is ongoing, this specific approach using a baboon model is relatively novel and has not been extensively tested.
Where this research is happening
-
University of Tx Md Anderson Can Ctr
Houston, United States Active
Researchers
- Principal investigator: Mulholland, Michele M — University of Tx Md Anderson Can Ctr
- Study coordinator: Mulholland, Michele M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.