Investigating cognitive and quality of life outcomes after CAR T-cell therapy for lymphoma
Neurocognitive and Patient-Reported Outcomes after Chimeric Antigen Receptor T-Cell Therapy: A Controlled Comparison
This study is looking at how CAR T-cell therapy for large B-cell lymphoma affects thinking skills and quality of life in patients, comparing them to people without cancer, and will involve some fun online tests and questionnaires to see how everyone is doing before and after treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | H. Lee Moffitt Cancer Ctr & Res Inst NIH-funded |
| Lab location | 1 site (Tampa, United States) |
| Project ID | NIH-10910110 on NIH RePORTER |
What this research studies
This research focuses on understanding how chimeric antigen receptor (CAR) T-cell therapy affects cognitive function and patient-reported outcomes in individuals with relapsed or refractory large B-cell lymphoma. The study will involve 204 patients receiving CAR T-cell therapy and 102 matched individuals without cancer, assessing their cognitive abilities and quality of life before treatment and at three and twelve months afterward. Participants will engage in internet-based neuropsychological tests, complete validated questionnaires, and use smartphone assessments to track their cognitive health and related symptoms over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with relapsed or refractory large B-cell lymphoma who are undergoing CAR T-cell therapy.
Not a fit: Patients who are not undergoing CAR T-cell therapy or those with other types of cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide valuable insights into the cognitive and quality of life impacts of CAR T-cell therapy, helping to improve patient care and survivorship strategies.
How similar studies have performed: Previous research has shown promising results in understanding cognitive outcomes in cancer therapies, but this specific focus on CAR T-cell therapy is relatively novel.
Where this research is happening
Tampa, United States
- H. Lee Moffitt Cancer Ctr & Res Inst — Tampa, United States (Active)
Researchers
- Principal investigator: Jim, Heather S.l. — H. Lee Moffitt Cancer Ctr & Res Inst
- Study coordinator: Jim, Heather S.l.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.