Investigating circular RNAs and their role in Alzheimer's disease
Circular RNAs and their interactions with RNA-binding proteins to modulate AD-related neuropathology
This study is looking at how certain molecules in our cells, called circular RNAs and RNA-binding proteins, work together and might play a role in the development of Alzheimer's disease and similar conditions, with the hope of finding new ways to understand and tackle these brain disorders.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10865070 on NIH RePORTER |
What this research studies
This research focuses on understanding how circular RNAs (circRNAs) and RNA-binding proteins (RBPs) interact and influence the development of Alzheimer's disease and related dementias. By examining these interactions, the study aims to uncover new biological mechanisms that contribute to neurodegeneration. The approach involves analyzing genetic variants and their effects on circRNA production and function, particularly in neuronal tissues. This could lead to insights into how these molecules may disrupt normal cellular processes in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related dementias.
Not a fit: Patients with non-neurological conditions or those without any form of dementia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic targets for treating Alzheimer's disease and related dementias.
How similar studies have performed: While the exploration of circRNAs in neurodegeneration is a relatively novel area, previous genomic studies have shown promise in understanding similar mechanisms in other neurological disorders.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Zhang, Xiaoling — Boston University Medical Campus
- Study coordinator: Zhang, Xiaoling
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.