Investigating cholesterol metabolism in aggressive colorectal cancer
Official title: Cholesterol metabolism in mesenchymal colorectal cancer
Funded at Weill Medical Coll of Cornell Univ · NIH-10987036 · Data updated 2026-11-12
This study is looking at how cholesterol affects the growth of a tough type of colorectal cancer, with the goal of finding new ways to treat it, so patients can have better options in the future.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | December 9, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $523,143 |
| NIH project number | 5R01CA275846-03 |
| Project ID | NIH-10987036 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with mesenchymal colorectal cancer, particularly those with a microsatellite stable phenotype.
✕Less likely to help
Patients with other types of colorectal cancer or those who do not have mesenchymal characteristics may not benefit from this research.
What this research studies
This research focuses on understanding how cholesterol metabolism contributes to the aggressive nature of mesenchymal colorectal cancer (CRC). By identifying specific vulnerabilities in this cancer type, the study aims to develop new therapeutic strategies. The approach involves analyzing human cancer samples and utilizing mouse models to explore the role of certain proteins in cancer progression and cholesterol biosynthesis. Patients may benefit from insights that could lead to more effective treatments for this challenging cancer subtype.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients with aggressive mesenchymal colorectal cancer.
How similar studies have gone: Previous research has shown promising results in targeting metabolic pathways in cancer, suggesting potential for success in this novel approach.
Where this research is happening
-
Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Moscat, Jorge — Weill Medical Coll of Cornell Univ
- Study coordinator: Moscat, Jorge
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.