Investigating cholesterol management in veterans with diabetes and cardiovascular disease risk
Official title: BLRD Research Career Scientist Award Application
Funded at Jesse Brown VA Medical Center · NIH-11183549 · Data updated 2026-11-12
This study is looking at new ways to help veterans with diabetes and heart issues lower their bad cholesterol levels by understanding how their gut affects cholesterol, so they can stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jesse Brown VA Medical Center NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | April 1, 2020 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| NIH project number | 2IK6BX005243-06 |
| Project ID | NIH-11183549 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are veterans with diabetes and high cholesterol levels who are at risk for cardiovascular diseases.
✕Less likely to help
Patients who do not have diabetes or cardiovascular disease risk factors may not benefit from this research.
What this research studies
This research focuses on the unique challenges faced by veterans who have a higher prevalence of diabetes and cardiovascular diseases. It aims to explore novel therapeutic interventions to effectively lower LDL cholesterol levels in high-risk patients. The approach involves studying gut-related mechanisms that regulate cholesterol absorption and metabolism, particularly through the intestinal cholesterol transporter NPC1L1. By understanding these pathways, the research seeks to develop better strategies for managing hypercholesterolemia and its associated health risks.
Why it matters
Potential benefit: If successful, this research could lead to improved cholesterol management and reduced cardiovascular disease risk for veterans.
How similar studies have gone: Previous research has shown promise in targeting gut mechanisms for cholesterol management, indicating potential for success in this approach.
Where this research is happening
-
Jesse Brown VA Medical Center
Chicago, United States Active
Researchers
- Principal investigator: Alrefai, Waddah a. — Jesse Brown VA Medical Center
- Study coordinator: Alrefai, Waddah a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.