Investigating chloride channels in blood vessel problems related to diabetes
Chloride channels in diabetic vascular disease
['FUNDING_R01'] · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · NIH-10739305
This study is looking at how type-2 diabetes impacts blood vessels and how certain channels in muscle cells help control blood vessel function, with the hope of finding new ways to treat heart and blood vessel problems that can come with diabetes.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF TENNESSEE HEALTH SCI CTR (nih funded) |
| Locations | 1 site (MEMPHIS, UNITED STATES) |
| Trial ID | NIH-10739305 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how diabetes affects blood vessels, particularly in patients with type-2 diabetes. It examines the role of chloride channels in vascular smooth muscle cells, which are crucial for regulating blood vessel contraction. By studying how diabetes alters the expression and activity of these channels, the research aims to uncover mechanisms that lead to vascular dysfunction and increased cardiovascular disease risk. Patients may benefit from insights that could lead to new treatments for vascular complications associated with diabetes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with type-2 diabetes who may be experiencing vascular complications.
Not a fit: Patients without diabetes or those with other unrelated cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating vascular complications in diabetic patients.
How similar studies have performed: Previous research has shown promising results in understanding ion channels in vascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
MEMPHIS, UNITED STATES
- UNIVERSITY OF TENNESSEE HEALTH SCI CTR — MEMPHIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LEO, M. DENNIS MARCUS — UNIVERSITY OF TENNESSEE HEALTH SCI CTR
- Study coordinator: LEO, M. DENNIS MARCUS
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Arterial Obstructive Diseases, Arterial Obstructive Disorder, Arterial Occlusive Disorder, Arterial Occlusive Diseases