Investigating chemical changes in DNA and RNA
Chemical Modifications in Regulatory Regions of DNA and RNA
This study is looking at how changes in DNA and RNA can affect gene activity, especially in conditions like Cockayne syndrome, to help us understand how these changes might relate to health and disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project ID | NIH-11090333 on NIH RePORTER |
What this research studies
This research focuses on understanding the chemical modifications that occur in DNA and RNA, which can affect how genes are regulated. By developing advanced sequencing methods, the team aims to identify where these modifications happen and how they influence biological processes. The study will also explore the roles of specific DNA repair proteins in managing these modifications, particularly under conditions of oxidative stress or inflammation. Patients may benefit from insights gained about how these changes relate to diseases like Cockayne syndrome.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with genetic disorders, particularly those affected by Cockayne syndrome or related conditions.
Not a fit: Patients with conditions unrelated to DNA or RNA modifications may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for diagnosing and treating genetic disorders linked to DNA and RNA modifications.
How similar studies have performed: Previous research has successfully identified similar chemical modifications in DNA and RNA, indicating a promising avenue for further exploration.
Where this research is happening
Salt Lake City, United States
- University of Utah — Salt Lake City, United States (Active)
Researchers
- Principal investigator: Burrows, Cynthia J — University of Utah
- Study coordinator: Burrows, Cynthia J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.