Investigating changes in tissue that support ovarian cancer spread
Official title: Elevated collagen I and fibronectin in the ovarian cancer pre-metastatic niche
Funded at University of Wisconsin-Madison · NIH-11060424 · Data updated 2026-11-12
This study is looking at how high-grade serous ovarian cancer spreads in the body by examining changes in a fatty tissue called the omentum, with the hope of finding new ways to slow down or stop the cancer from spreading.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | December 11, 2024 |
| Project end | November 30, 2029 |
| Funding year | 2025 |
| Award (this year) | $612,288 |
| NIH project number | 1R01CA290693-01A1 |
| Project ID | NIH-11060424 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with early-stage high-grade serous ovarian cancer.
✕Less likely to help
Patients with advanced-stage ovarian cancer or those with other types of cancer may not benefit from this research.
What this research studies
This research focuses on understanding how high-grade serous ovarian cancer (HGSOC) spreads rapidly within the body. It examines the changes in the omentum, a fatty tissue in the abdomen, that occur before cancer cells metastasize. By analyzing the composition of this tissue, particularly the levels of collagen and fibronectin, the research aims to uncover mechanisms that facilitate tumor growth and spread. The ultimate goal is to identify potential therapeutic strategies that could slow down or prevent the metastasis of ovarian cancer.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve survival rates for patients with ovarian cancer.
How similar studies have gone: Previous research has shown promising results in understanding the pre-metastatic niche in other cancers, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Kreeger, Pamela K — University of Wisconsin-Madison
- Study coordinator: Kreeger, Pamela K
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.