Investigating changes in the glioblastoma tumor environment during new therapies
Temporal analysis of the GBM tumor microenvironment during myeloid cell activating therapy
This study is looking at how glioblastoma tumors change when treated, to find better ways to use the immune system to fight the cancer, which could help patients get more effective treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11088211 on NIH RePORTER |
What this research studies
This research focuses on understanding the tumor microenvironment (TME) in glioblastoma multiforme (GBM), which can change rapidly in response to treatments. By using innovative techniques to analyze the TME over time, the study aims to identify how immune cells and other factors within the tumor adapt to therapies. The goal is to develop more effective treatments by targeting specific immune cells with new therapies that have shown promise in preclinical models. Patients may benefit from insights that lead to improved therapeutic strategies for GBM.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with glioblastoma multiforme who are undergoing treatment.
Not a fit: Patients with other types of brain tumors or those not currently receiving treatment for glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving patient outcomes.
How similar studies have performed: Other research has shown success with similar approaches in understanding tumor microenvironments and developing targeted therapies.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Weissleder, Md, Phd, Ralph — Massachusetts General Hospital
- Study coordinator: Weissleder, Md, Phd, Ralph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.