Investigating changes in the brain's glutamate system in Alzheimer's disease
Imaging of glutamatergic system changes in Alzheimer's disease in vivo
This study is looking at how a part of the brain that helps with memory and learning changes in people with Alzheimer's disease, hoping to find clues that could lead to new treatments to slow down the disease before symptoms appear.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10814209 on NIH RePORTER |
What this research studies
This research focuses on understanding how the glutamatergic system, which is crucial for memory and learning, is affected in individuals with Alzheimer's disease. By using advanced imaging techniques, the study aims to identify specific molecular changes in the brain that occur before the onset of symptoms. This could help in developing new therapies aimed at slowing down or stopping the progression of Alzheimer's. The research will involve both observational assessments and imaging to gather data on brain function and structure.
Who could benefit from this research
Good fit: Ideal candidates for this research include older adults who are experiencing early signs of cognitive decline or have been diagnosed with Alzheimer's disease.
Not a fit: Patients with other forms of dementia or those who are not experiencing cognitive decline may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments that slow or halt the progression of Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of glutamatergic neurotransmission in Alzheimer's, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Reddy, Ravinder — University of Pennsylvania
- Study coordinator: Reddy, Ravinder
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.