Investigating changes in brain cells due to alcohol dependence in mice
Functional, Structural and Epigenetic Modifications of Cerebellar Purkinje Neurons in Alcohol-Dependent Mice
['FUNDING_CAREER'] · MEDICAL UNIVERSITY OF SOUTH CAROLINA · NIH-10893501
This study is looking at how alcohol dependence affects certain brain cells in mice, which could help us understand more about alcohol's impact on the brain and lead to better treatments for people struggling with alcohol use.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MEDICAL UNIVERSITY OF SOUTH CAROLINA (nih funded) |
| Locations | 1 site (CHARLESTON, UNITED STATES) |
| Trial ID | NIH-10893501 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how alcohol dependence affects the cerebellar Purkinje neurons in mice. The principal investigator, Dr. Paula Zamudio-Bulcock, will utilize advanced techniques such as electrophysiology and microscopy to study the functional, structural, and epigenetic changes in these brain cells. By using animal models, the research aims to uncover the underlying mechanisms of alcohol's impact on the brain, which could inform future treatments for alcohol dependence. The project also emphasizes the investigator's career development in the field of alcohol research.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals with alcohol dependence or those at risk of developing alcohol use disorders.
Not a fit: Patients who do not consume alcohol or have no history of alcohol dependence may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the biological effects of alcohol dependence, potentially guiding the development of targeted therapies for individuals struggling with alcohol use disorders.
How similar studies have performed: Previous research has shown promising results in understanding the effects of alcohol on brain function, suggesting that this approach could yield valuable insights.
Where this research is happening
CHARLESTON, UNITED STATES
- MEDICAL UNIVERSITY OF SOUTH CAROLINA — CHARLESTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ZAMUDIO-BULCOCK, PAULA ANDREA — MEDICAL UNIVERSITY OF SOUTH CAROLINA
- Study coordinator: ZAMUDIO-BULCOCK, PAULA ANDREA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.