Investigating cerebrospinal fluid exchange in Alzheimer's disease using advanced MRI techniques
Official title: Cerebrospinal fluid exchange in Alzheimer's disease characterized by advanced MRI techniques
Funded at Hugo W. Moser Res Inst Kennedy Krieger · NIH-11000263 · Data updated 2026-11-12
This study is looking at how the flow of a special fluid in the brain changes in people with Alzheimer's disease, using advanced MRI scans to help find early signs of the condition and improve how we diagnose it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Hugo W. Moser Res Inst Kennedy Krieger NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | December 15, 2022 |
| Project end | November 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $670,955 |
| NIH project number | 5R01AG080104-03 |
| Project ID | NIH-11000263 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals showing early signs of cognitive decline or those at risk for Alzheimer's disease.
✕Less likely to help
Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
What this research studies
This research focuses on understanding how cerebrospinal fluid (CSF) circulation is affected in Alzheimer's disease (AD) by utilizing advanced MRI techniques. The study aims to identify new biomarkers for early detection of AD by examining the glymphatic system, which plays a crucial role in clearing waste from the brain. By employing non-invasive imaging methods, researchers will assess the secretion and absorption of CSF in real-time, providing insights into neurodegeneration and cognitive impairment associated with AD. This approach could lead to improved diagnostic methods and a better understanding of the disease's progression.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnoses of Alzheimer's disease, potentially improving treatment outcomes for patients.
How similar studies have gone: Other research has shown promise in using advanced imaging techniques to study brain function and disease progression, indicating that this approach could yield valuable insights.
Where this research is happening
-
Hugo W. Moser Res Inst Kennedy Krieger
Baltimore, United States Active
Researchers
- Principal investigator: Xu, Jiadi — Hugo W. Moser Res Inst Kennedy Krieger
- Study coordinator: Xu, Jiadi
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.