Investigating cellular aging and immune function in human lymphoid organs
Core C: Biological Analysis Core
This study is looking at how aging cells in important parts of your immune system, like bone marrow and lymph nodes, affect your health as you get older, and it hopes to find ways to help you stay healthier for longer.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10904923 on NIH RePORTER |
What this research studies
This research focuses on understanding how cellular senescence affects the function of human lymphoid organs, such as bone marrow and lymph nodes, which play crucial roles in immune response and aging. By utilizing advanced technologies like single-cell sequencing and spatial molecular imaging, the study aims to create detailed maps of senescent cells and their environments within these tissues. This approach will help uncover the relationship between aging, immune function, and disease development, potentially leading to new strategies for improving healthspan and lifespan.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing age-related immune decline or those with conditions linked to cellular senescence.
Not a fit: Patients with acute infections or those who do not exhibit signs of immune dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that enhance immune function and promote healthier aging.
How similar studies have performed: Other research has shown promising results in understanding cellular senescence and its implications for aging and immune function, suggesting that this approach could yield significant insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.