Investigating cell types in different species at a single cell level
Comparing cell types across mutants and species at single cell resolution
This study is looking at tiny cells from a small worm called Caenorhabditis elegans and its relatives to see how they work differently and how genes are turned on or off, which could help us understand more about how living things grow and how diseases happen.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10895979 on NIH RePORTER |
What this research studies
This research focuses on understanding the diversity of cell types and gene expression regulation by comparing single cells from the model organism Caenorhabditis elegans with related nematode species. The project aims to develop methods to identify homologous cells across different genetic conditions and evolutionary backgrounds. By generating large datasets of single cell RNA-sequencing, the researchers will analyze how gene expression varies among these species, which could provide insights into developmental biology and disease mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with genetic conditions or diseases that affect cellular function and development.
Not a fit: Patients with conditions unrelated to cellular biology or those not affected by genetic variations may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of cellular functions and gene regulation, potentially leading to new therapeutic strategies for various diseases.
How similar studies have performed: Previous research has shown success in using single cell RNA-sequencing to uncover gene expression patterns, making this approach promising for further exploration.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Murray, John Isaac — University of Pennsylvania
- Study coordinator: Murray, John Isaac
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.