Investigating cell differences in the brain related to aging and Alzheimer's disease
Molecular Diversity Among Hippocampal and Entorhinal Cells in Aging and Alzheimer's Disease
This study is looking at how certain brain cells change as we age and in Alzheimer's disease, hoping to find clues that could lead to new treatments, which could help patients understand their condition better and possibly improve their care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10891756 on NIH RePORTER |
What this research studies
This research focuses on understanding how different types of cells in the hippocampus and entorhinal cortex of the brain change with aging and in Alzheimer's disease. By using advanced techniques like single nuclear RNA sequencing and chromatin accessibility assays, the researchers aim to identify specific molecular signatures that differentiate vulnerable and resilient cell types in these brain regions. This could provide insights into the mechanisms behind Alzheimer's disease and help identify potential targets for treatment. Patients may benefit from a better understanding of the disease and potential new therapies developed from this research.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who are experiencing symptoms of Alzheimer's disease or are at risk for developing it.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and therapies for Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in understanding cellular changes in Alzheimer's disease, but this approach using advanced sequencing techniques is relatively novel.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sestan, Nenad — Yale University
- Study coordinator: Sestan, Nenad
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.