Investigating cell death processes in development and disease
Official title: Nuclear and chromatin aberrations during non-apoptotic cell death in C. elegans and mammals
Funded at Rockefeller University · NIH-10906950 · Data updated 2026-11-12
This study is looking at how certain types of cell death, which are different from the usual way cells die, happen in the body, and it aims to help us understand diseases like cancer and neurodegenerative disorders by using tiny worms and mice to learn more about these processes.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $124,999 |
| NIH project number | 5K99GM151467-02 |
| Project ID | NIH-10906950 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals affected by neurodegenerative diseases, aggressive cancers, or age-related conditions.
✕Less likely to help
Patients with conditions unrelated to cell death processes or those not exhibiting the specific types of cell death being studied may not benefit from this research.
What this research studies
This research focuses on understanding the molecular mechanisms behind non-apoptotic cell death, which plays a crucial role in vertebrate development and various diseases. By studying the organization of nuclear and chromatin structures, the research aims to uncover how these changes contribute to cell death processes that are distinct from the well-known apoptosis. Using the model organism C. elegans and developing mouse models, the research will explore the regulatory processes involved in these cell death mechanisms. This could lead to insights into conditions such as neurodegenerative diseases and cancers.
Why it matters
Potential benefit: If successful, this research could provide new insights into the mechanisms of cell death, potentially leading to novel therapeutic strategies for diseases characterized by abnormal cell death.
How similar studies have gone: While apoptosis has been extensively studied, the exploration of non-apoptotic cell death mechanisms is relatively novel, suggesting that this research could pave the way for new discoveries.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Yarychkivska, Olga — Rockefeller University
- Study coordinator: Yarychkivska, Olga
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.