Investigating cell death mechanisms in sepsis
Necroinflammatory Cell Death in Sepsis
This study is looking at how certain proteins in your body might affect the immune response during sepsis, a serious infection, to help doctors better understand and treat the condition for patients in the emergency room and ICU.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10892663 on NIH RePORTER |
What this research studies
This research focuses on understanding the complex immune response in sepsis, a severe infection that can lead to organ failure. It aims to explore the roles of specific proteins, TRAIL and RIPK3, in the process of necroinflammatory cell death, which may contribute to the worsening of sepsis. By examining these proteins at different stages in patients from the emergency department and ICU, the research seeks to identify patterns that could predict the progression of sepsis and improve patient outcomes. The study will involve creating a cohort of patients to analyze these mechanisms over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients presenting with sepsis or at high risk of developing sepsis in emergency and intensive care settings.
Not a fit: Patients with non-infectious conditions or those not presenting with sepsis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification of patients at risk for severe sepsis and improved treatment strategies.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in sepsis, but this specific approach to necroinflammatory cell death is relatively novel.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Schenck, Edward James — Weill Medical Coll of Cornell Univ
- Study coordinator: Schenck, Edward James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.