Investigating CCRL2's role in myelodysplastic syndrome
CCRL2 as a Regulator of Growth and Novel Target in Myelodysplastic Syndrome
This study is looking at how a specific gene called CCRL2 affects the growth of harmful cells in myelodysplastic syndrome (MDS), especially in men, to find new ways to improve treatment for people with this blood disorder.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11076301 on NIH RePORTER |
What this research studies
This research focuses on understanding how the CCRL2 gene influences the growth of malignant cells in myelodysplastic syndrome (MDS), a serious blood disorder. The study aims to identify the mechanisms by which CCRL2 contributes to the survival and proliferation of these harmful cells, particularly in men who are affected more severely than women. By exploring the interactions between CCRL2 and other cellular components, the research seeks to uncover potential therapeutic targets that could improve treatment outcomes for patients with MDS.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with high-risk myelodysplastic syndrome, particularly those who have not responded well to current treatments.
Not a fit: Patients with low-risk myelodysplastic syndrome or those without a confirmed diagnosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies that improve survival rates and quality of life for patients with myelodysplastic syndrome.
How similar studies have performed: Previous research has shown promising results in targeting similar pathways in blood disorders, suggesting that this approach could be effective.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Karantanos, Theodoros — Johns Hopkins University
- Study coordinator: Karantanos, Theodoros
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.