Investigating cartilage injury and recovery in a piglet model of Legg-Calve-Perthes disease
Official title: Spatialomics and quantitative MRI of ischemic injury in a piglet model of Legg-Calve-Perthes disease
Funded at University of Minnesota · NIH-10915014 · Data updated 2026-11-12
This study is looking at how a lack of blood flow affects the growth of cartilage in young pigs with Legg-Calve-Perthes disease, which can cause hip issues in kids, and it aims to find out how a specific treatment might help improve their condition.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $132,408 |
| NIH project number | 5K01OD034070-02 |
| Project ID | NIH-10915014 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children diagnosed with Legg-Calve-Perthes disease who may benefit from innovative treatment approaches.
✕Less likely to help
Patients who are not affected by Legg-Calve-Perthes disease or those who are adults will not receive benefits from this research.
What this research studies
This research focuses on understanding how ischemic injury affects the growth cartilage in piglets with Legg-Calve-Perthes disease, a condition that can lead to hip problems in children. Using advanced techniques like spatialomic profiling and quantitative MRI, the study aims to identify specific genes involved in cartilage growth disturbances and evaluate the effects of a treatment called transphyseal drilling. By examining these factors, the research seeks to uncover insights that could improve treatment strategies for children suffering from this condition.
Why it matters
Potential benefit: If successful, this research could lead to better treatment options for children with Legg-Calve-Perthes disease, potentially improving their growth and reducing complications.
How similar studies have gone: While this approach is novel in the context of Legg-Calve-Perthes disease, similar methodologies have shown promise in other orthopedic conditions.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Armstrong, Alexandra Pr — University of Minnesota
- Study coordinator: Armstrong, Alexandra Pr
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.