Investigating cardiovascular risks in adults with sickle cell disease
2/2 Sickle Cell Disease and CardiovAscular Risk - Red cell Exchange Trial (SCD-CARRE Trial)
This study is looking at how sickle cell disease can affect heart health in adults, especially by causing problems like high blood pressure in the lungs and heart disease, and it uses simple tests to find out who might be at greater risk so that better care can be provided.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11076781 on NIH RePORTER |
What this research studies
This research focuses on understanding the cardiovascular complications that arise in adults with sickle cell disease (SCD), particularly how chronic hemolytic anemia and vaso-occlusive events lead to conditions like pulmonary hypertension and heart disease. The study utilizes non-invasive tests, such as Doppler-echocardiography and NT-proBNP levels, to assess heart function and risks in these patients. By identifying those at higher risk, the research aims to improve monitoring and potentially develop targeted therapies for better management of cardiovascular health in SCD patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sickle cell disease, particularly those showing signs of elevated pulmonary artery pressure or heart dysfunction.
Not a fit: Patients without sickle cell disease or those who do not exhibit cardiovascular complications related to the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for cardiovascular complications in adults with sickle cell disease.
How similar studies have performed: Previous research has indicated significant associations between elevated echocardiographic measurements and adverse outcomes in sickle cell disease, suggesting that this approach has potential for impactful findings.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Brooks, Maria Mori — University of Pittsburgh at Pittsburgh
- Study coordinator: Brooks, Maria Mori
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.