Investigating cardiovascular risks in adults with sickle cell disease
Sickle Cell Disease and Cardiovascular Risk- Red Cell Exchange SCD-CARRE
This study is looking at how sickle cell disease affects heart and lung health in adults, using simple tests to find out if patients are at risk for heart problems, so we can help them stay healthier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11076765 on NIH RePORTER |
What this research studies
This research focuses on understanding how sickle cell disease (SCD) affects cardiovascular health in adults. It examines the long-term impacts of hemolytic anemia and vaso-occlusive events on heart and lung function, particularly looking for signs of pulmonary hypertension and heart disease. The study uses non-invasive tests, such as Doppler-echocardiography and blood biomarkers, to assess cardiovascular risks in patients with SCD. By identifying high-risk individuals, the research aims to improve patient outcomes through better monitoring and potential therapies.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with sickle cell disease who are at risk for cardiovascular complications.
Not a fit: Patients without sickle cell disease or those who are not adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved monitoring and treatment strategies for cardiovascular complications in patients with sickle cell disease.
How similar studies have performed: Previous research has shown that monitoring cardiovascular health in sickle cell patients can lead to better understanding and management of their condition, indicating a promising avenue for this study.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Gladwin, Mark T — University of Maryland Baltimore
- Study coordinator: Gladwin, Mark T
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.