Investigating cardiovascular risk in rheumatoid arthritis using bioinformatics
Official title: Mentoring Patient-Oriented Research Leveraging Bioinformatics to Study CV Risk in Rheumatic Disease
Funded at Brigham and Women's Hospital · NIH-11032134 · Data updated 2026-11-12
This study is looking at how rheumatoid arthritis can increase the risk of heart disease, and it’s for people over 40 with RA who have at least one heart risk factor, to help find out who might need extra care to protect their heart.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $147,917 |
| NIH project number | 1K24AR085342-01 |
| Project ID | NIH-11032134 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are rheumatoid arthritis patients over the age of 40 who have at least one cardiovascular risk factor.
✕Less likely to help
Patients with rheumatoid arthritis who are under 40 years old or do not have any cardiovascular risk factors may not benefit from this research.
What this research studies
This research focuses on understanding the increased risk of cardiovascular disease in patients with rheumatoid arthritis (RA). It aims to identify patients who may be at higher risk for atherosclerotic cardiovascular disease (ASCVD) by using advanced bioinformatics techniques and biomarkers like high sensitivity cardiac troponin (hs-cTn). The study will recruit RA patients over 40 years old with at least one cardiovascular risk factor to undergo testing and screening for coronary artery calcium. By improving risk stratification, the research seeks to better target primary prevention strategies, such as statin therapy, for those who need it most.
Why it matters
Potential benefit: If successful, this research could lead to more effective prevention strategies for cardiovascular disease in patients with rheumatoid arthritis.
How similar studies have gone: Previous research has shown promising results in using biomarkers like hs-cTn for cardiovascular risk assessment in similar patient populations.
Where this research is happening
-
Brigham and Women's Hospital
Boston, United States Active
Researchers
- Principal investigator: Liao, Katherine Phoenix — Brigham and Women's Hospital
- Study coordinator: Liao, Katherine Phoenix
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.